[2017] Strong Contact Coupling of Neuronal Growth Cones with Height-controlled Vertical Silicon Nanocolumns > 최근연구

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  • 숙명여자대학교 화학과 대학원
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    • [2017] Strong Contact Coupling of Neuronal Growth Cones with Height-controlled Vertical Silicon Nanocolumns

      autohr : Seong-Min Kim, Seyeong Lee, Dongyoon Kim, Dong-Hee Kang, Kisuk Yang, Seung-Woo Cho, Jin Seok Lee, Insung S. Choi, Kyungtae Kang, and Myung-Han Yoon
      journal : Nano Research 2017

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      ABSTRACT: In this study, we report that height-controlled vertically etched silicon nano-column arrays (vSNAs) induce strong growth cone-to-substrate coupling and accelerate In vitroneurite development while preserving the essential features of initial neurite formation. Large-scale preparation of vSNAs with flat head morphology enabled the generation of well-controlled topographical stimulation without cellular impalement. A systematic analysis on topography-induced variations on cellular morphology and cytoskeletal dynamics was conducted. In addition, neurite development on the grid-patterned vSNAs exhibited preferential adhesion to the nanostructured region and outgrowth directionality. The arrangement of cytoskeletal proteins and the expression of a focal adhesion complex indicated that a strong coupling existed between the underlying nanocolumns and growth cones. Furthermore, the height-controlled nanocolumn substrates differentially modulated neurite polarization and elongation. Our findings provide an important insight into neuron-nanotopographyinteractions and their role in cell adhesion and neurite development.

       

      KEYWORDS: vertical silicon nanostructures, metal-assisted chemical etching,  primary hippocampal neurons, neurite outgrowth, cytoskeletal dynamics

       



      c5eaadfe0eea6183d0850a02b2bb2a9e_1529038

      Author : Seong-Min Kim, Seyeong Lee, Dongyoon Kim, Dong-Hee Kang, Kisuk Yang, Seung-Woo Cho, Jin Seok Lee, Insung S. Choi, Kyungtae Kang, and Myung-Han Yoon

       

      Journal : Nano Research 2017

       

      Publication Date : 2017.11.07 

       


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      This publication is from Prof. Jin Seok Lee’s collaboration research

       

       

       

       

       

      [이 게시물은 관리자님에 의해 2018-06-15 14:34:50 최근소식에서 이동 됨]

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